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Long-Term Antioxidant Metal-Organic Frameworks.

Woojin Park1,2, Sanghyun Park1,3, Ki-Youb Park1

  • 1Korea Science Academy of KAIST, 105-47 Baegyanggwanmun-ro, Busanjin-gu, Busan 47162, Republic of Korea.

ACS Omega
|May 20, 2024
PubMed
Summary

Metal-organic frameworks (MOFs) offer a novel solution for long-term antioxidant delivery. FeTHQ, a MOF utilizing tetrahydroxy-1,4-benzoquinone, demonstrates sustained antioxidant effects for up to seven days.

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Area of Science:

  • Materials Science
  • Biochemistry
  • Nanotechnology

Background:

  • Metabolic free radicals cause cell damage and cancer due to high reactivity.
  • Dietary antioxidants are effective but short-lived.
  • Metal-organic frameworks (MOFs) are crystalline polymers with potential for controlled release applications.

Purpose of the Study:

  • To investigate the use of MOFs with antioxidants as ligands for sustained free radical scavenging.
  • To evaluate the biocompatibility, particle size, and long-term antioxidant efficacy of these novel MOFs.
  • To explore microwave synthesis for optimizing MOFs for in vivo applications.

Main Methods:

  • MOF synthesis with antioxidant ligands.
  • Cell treatment with MOFs and precursors, followed by WST-8 assay for biocompatibility.
  • Transmission Electron Microscopy (TEM) and ImageJ for particle size analysis.
  • UV-vis spectroscopy for quantifying antioxidant release.

Main Results:

  • Fe-based FeTHQ, using tetrahydroxy-1,4-benzoquinone (THQ) as a ligand, showed significant long-term antioxidant activity.
  • Antioxidant effects from FeTHQ persisted for up to 7 days.
  • Microwave synthesis produced FeTHQ particles suitable for in vivo applications.

Conclusions:

  • Antioxidant-based MOFs, specifically FeTHQ, represent a promising strategy for sustained free radical neutralization.
  • FeTHQ exhibits favorable biocompatibility and particle characteristics for potential in vivo use.
  • The developed MOF technology offers a new avenue for managing oxidative stress-related conditions.