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Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A
Bo-Na Liu1, Xiao-Li Gao1, Ying Piao2
1Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110015, Liaoning Province, China.
Background:
Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure.
Aim:
To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC.
Methods:
Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses.
Results:
From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions.
Conclusion:
The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.
Insights
This study maps research on nanomaterials for gastric cancer (GC), revealing key areas in diagnosis, treatment, and cellular effects. Future trends include complexes, silver nanoparticles, and green synthesis for advanced GC applications.
Area of Science:
- Nanotechnology
- Oncology
- Materials Science
Background:
- Previous reviews summarized nanomaterials for gastrointestinal tumors.
- Research hotspots and trends in nanomaterial applications for gastric cancer (GC) require clarification.
Purpose of the Study:
- To map the knowledge structure and evolutionary trends of research on nanomaterial applications in gastric cancer (GC).
Main Methods:
- Systematic review and bibliometric analysis of publications from the Web of Science Core Collection (2000-2022).
- Bibliometric and visualization analyses were performed using VOSviewer and CiteSpace.
Main Results:
- Research on nanomaterials in GC has rapidly advanced from 2000 to 2022.
- Keyword analysis identified three main research clusters: GC treatment, GC diagnosis (including toxicity), and effects on GC cell behavior.
- Emerging research directions include complexes, silver nanoparticles, and green synthesis.
Conclusions:
- Nanomaterial applications in GC diagnosis and treatment have been central themes.
- Understanding the mechanisms of nanomaterial effects on GC cells is a significant area of study.
