Five years of advances in electrochemical analysis of protein biomarkers in lung cancer: a systematic review

Matías Regiart ¹, Martín A Fernández-Baldo ¹, Bernardino Alcázar Navarrete ^2,3,4

⁰Instituto de Química San Luis (INQUISAL), Departamento de Química, Universidad Nacional de San Luis, CONICET, San Luis, Argentina.

Frontiers in Chemistry +

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May 20, 2024

View abstract on PubMed

Summary

Early detection of lung cancer biomarkers is crucial. Electrochemical methods like biosensors offer faster, cheaper, and simpler ways to find these vital indicators in clinical samples.

Area Of Science

Biomedical Engineering
Analytical Chemistry
Oncology

Background

Lung cancer is a leading cause of cancer mortality globally.
Early detection of specific biomarkers is essential for effective treatment and improved patient outcomes.
Current diagnostic methods can be time-consuming, costly, and complex.

Purpose Of The Study

To review and analyze electrochemical methods for lung cancer biomarker detection.
To highlight the advantages of electrochemical techniques, including microfluidic devices and biosensors.
To provide a comprehensive resource for researchers and clinicians in lung cancer diagnosis.

Main Methods

Review of existing scientific literature on electrochemical detection of lung cancer biomarkers.
Analysis of methodologies, including microfluidic devices and various biosensor platforms.
Evaluation of reported detection limits and performance metrics.

Main Results

Electrochemical methods demonstrate significant potential for rapid and sensitive lung cancer biomarker detection.
Microfluidic devices and biosensors offer reduced assay complexity, time, and cost compared to traditional methods.
A range of detection limits have been reported, showcasing the evolving capabilities of these techniques.

Conclusions

Electrochemical approaches are highly promising for the early and accurate diagnosis of lung cancer.
These methods can streamline the detection process, making it more accessible and efficient for clinical application.
Further research and development in this area will significantly contribute to lung cancer management.

Keywords:

biomarkers biosensors clinical analysis diagnosis electrochemical methods lung cancer