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Targeting lipid reprogramming in the tumor microenvironment by traditional Chinese medicines as a potential cancer

Qian Zuo1,2, Yingchao Wu1, Yuyu Hu2,3

  • 1State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

Heliyon
|May 20, 2024
PubMed

Insights

Cancer cells reprogram lipid metabolism, affecting growth and immune cells. Traditional Chinese medicine components show potential for regulating these metabolic shifts.

Area of Science:

  • Oncology
  • Cancer Metabolism
  • Lipidomics

Background:

  • Cancer cells exhibit metabolic reprogramming, with lipid metabolism gaining attention.
  • Lipidomics technologies enable detailed analysis of lipid profiles in tumors and the tumor microenvironment (TME).
  • Traditional Chinese Medicine (TCM) has historical use in cancer treatment and is explored for metabolic regulation.

Purpose of the Study:

  • To review key alterations in cancer lipid metabolism.
  • To discuss the impact of lipid reprogramming on tumor growth, metastasis, and immune cells within the TME.
  • To highlight TCM's role in modulating cancer lipid metabolism.

Main Methods:

  • Literature review focusing on lipid metabolism in cancer.
  • Analysis of lipidomics data and its implications.
  • Exploration of TCM's bioactive components and their mechanisms.

Main Results:

  • Key lipid reprogramming events include fatty acid synthesis, uptake, oxidation (FAO), and cholesterol accumulation.
  • Altered lipid metabolism influences tumor growth, metastasis, and immune cell function within the TME.
  • Specific TCM components demonstrate potential in targeting cancer lipid metabolic pathways.

Conclusions:

  • Lipid metabolism is a critical, yet understudied, aspect of cancer progression.
  • Targeting cancer lipid metabolism presents therapeutic opportunities.
  • TCM offers promising avenues for developing novel anti-cancer strategies by modulating lipid metabolism.
Keywords:
Fatty acidsLipid dropletLipid reprogrammingTraditional Chinese medicinesTumor microenvironmentde novo lipogenesis

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