JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Comparison of Prognosis and Metachronous Gastric Tumor Rates After Endoscopic Submucosal Dissection Between Gastric Neoplasm of Fundic Gland Type Neoplasms and Conventional Gastric Adenocarcinoma

  • 0Gastroenterology, Toranomon Hospital, Tokyo, JPN.
Cureus +

|

May 20, 2024

|

May 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Gastric neoplasm of the fundic gland type (GNFG) shows a good prognosis, similar to conventional gastric adenocarcinoma (CGA). Surveillance after endoscopic submucosal dissection (ESD) for GNFG should be comparable to CGA due to similar metachronous tumor rates.

Area Of Science

  • Gastroenterology
  • Oncology
  • Surgical Pathology

Background

  • Gastric neoplasm of the fundic gland type (GNFG) is recognized for its favorable prognosis.
  • Comparative data regarding GNFG prognosis and metachronous tumor development versus conventional gastric adenocarcinoma (CGA) is limited.
  • Understanding these differences is crucial for determining appropriate post-treatment surveillance strategies.

Purpose Of The Study

  • To compare the overall survival (OS), disease-specific survival, progression-free survival, and metachronous gastric tumor rates between GNFG and CGA.
  • To establish whether GNFG warrants a different surveillance protocol compared to CGA after endoscopic submucosal dissection (ESD).

Main Methods

  • A retrospective, single-center, matched-cohort study was conducted from January 2010 to December 2021.
  • GNFG cases from the ESD database were matched 1:4 with CGA controls based on age and sex.
  • Key outcomes assessed included OS, disease-specific survival, progression-free survival, and metachronous gastric tumor incidence.

Main Results

  • The study included 43 GNFG lesions and 164 matched CGA cases.
  • No significant difference in overall survival (OS) was observed between GNFG and CGA groups (P=0.81), with five-year OS rates of 90.9% and 92.9%, respectively.
  • Cumulative five-year metachronous gastric tumor rates were 6.6% for GNFG and 2.5% for CGA, with no statistically significant difference (P=0.17).

Conclusions

  • GNFG demonstrates a good prognosis, comparable to CGA, and is not statistically superior.
  • The incidence of metachronous gastric tumors after ESD for GNFG is not lower than that observed for CGA.
  • Current evidence suggests that GNFG should be managed with surveillance protocols similar to those for CGA following ESD.

Keywords: