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Goblet Cell Adenocarcinoma in the Stomach: A Case Report

  • 0Department of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, Hamamatsu, JPN.
Cureus +

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May 20, 2024

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May 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Goblet cell adenocarcinoma (GCA), a rare gastric cancer subtype, presents amphicrine features. This case highlights GCA

Area Of Science

  • Gastroenterology and Oncology
  • Surgical Pathology

Background

  • Goblet cell adenocarcinoma (GCA) is an amphicrine tumor typically found in the appendix.
  • Amphicrine tumors exhibit both exocrine and neuroendocrine differentiation.

Observation

  • A rare case of gastric GCA in an 80-year-old male presenting with epigastric pain.
  • Gastroscopy revealed gastric cancer, confirmed by histology post-total gastrectomy.

Findings

  • Histology showed a mixed tumor: moderately-differentiated tubular adenocarcinoma, mucinous adenocarcinoma, and GCA with goblet-like cells and neuroendocrine differentiation.
  • The GCA component constituted the largest tumor volume (5:4:1 ratio).
  • Regional lymph node metastasis exclusively involved the goblet-like cell component.

Implications

  • This case underscores the importance of recognizing GCA as a rare histologic subtype of gastric cancer.
  • Accurate diagnosis is crucial for understanding tumor behavior and guiding treatment strategies.
  • Further research into gastric GCA is warranted to elucidate its unique characteristics and clinical outcomes.

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