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Transforming growth factor beta-1 (TGF-β1) expression in patients with adenomyosis

  • 0Universidade Federal do Rio Grande do Sul Porto AlegreRS Brazil Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Revista Brasileira De Ginecologia E Obstetricia : Revista Da Federacao Brasileira Das Sociedades De Ginecologia E Obstetricia +

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May 20, 2024

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May 20, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Transforming growth factor beta-1 (TGF-β1) expression was evaluated in women with and without adenomyosis. This study found no significant difference in TGF-β1 levels between the groups, suggesting it is not a key factor in adenomyosis development.

Area Of Science

  • Gynecology
  • Cell Biology
  • Pathophysiology

Background

  • Adenomyosis is a common gynecological condition characterized by the presence of endometrial tissue within the myometrium.
  • Transforming growth factor beta-1 (TGF-β1) is a cytokine implicated in various cellular processes, including tissue remodeling and fibrosis, which may play a role in adenomyosis pathogenesis.

Purpose Of The Study

  • To investigate and compare the expression levels of TGF-β1 in the ectopic endometrium of patients diagnosed with adenomyosis versus control subjects without adenomyosis.

Main Methods

  • A prospective study involving 49 patients undergoing hysterectomy.
  • Immunohistochemistry was utilized to assess TGF-β1 expression in endometrial samples.
  • Statistical analysis included Student's t-test and multivariate logistic regression, with significance set at p < 0.05.

Main Results

  • No significant association was found between adenomyosis and factors such as smoking, miscarriage, number of pregnancies, curettage, pelvic pain, or myoma.
  • A significant association was observed between adenomyosis and abnormal uterine bleeding (AUB) and previous cesarean sections (p = 0.02 for both).
  • Mean TGF-β1 intensity in the ectopic endometrium of adenomyosis patients (184.17 ± 9.4) was not significantly different from that of control subjects (184.66 ± 16.08, p = 0.86).

Conclusions

  • TGF-β1 expression is not elevated in the ectopic endometrium of women with adenomyosis.
  • The findings do not support a role for increased TGF-β1 in the pathophysiology of adenomyosis.

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