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NTCdb: Single-cell transcriptome database of human inflammatory-associated diseases.

Chaochao Wang1, Ting Huyan1, Wuli Guo1

  • 1School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.

Computational and Structural Biotechnology Journal
|May 20, 2024
PubMed
Summary

A new database, NTCdb, offers comprehensive single-cell transcriptomics data for immune cells in inflammatory diseases. It aids researchers in understanding disease mechanisms and identifying therapeutic targets.

Keywords:
Cell communicationDatabaseImmunocytesInflammatory-associated diseaseSingle cell transcriptome

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Area of Science:

  • Biomedical research
  • Genomics
  • Immunology

Background:

  • Single-cell transcriptomics is increasingly used to study disease mechanisms at the cellular level.
  • Exponential growth in single-cell transcriptome data from clinical samples.
  • A gap exists in comprehensive databases for immunocytes in inflammatory diseases.

Purpose of the Study:

  • To develop a centralized human inflammatory-associated disease-based single-cell transcriptome database (NTCdb).
  • To provide a platform for exploring immune cell characteristics and disease mechanisms.
  • To facilitate the discovery of potential therapeutic targets and biomarkers.

Main Methods:

  • Integration of 1,023,166 cells from 11 tissues across 17 inflammatory diseases into NTCdb.
  • Application of a uniform data processing pipeline.
  • Inclusion of analytical tools such as cell communication, enrichment, and Pseudo-Time analysis.

Main Results:

  • NTCdb provides a unified resource for studying immune cell heterogeneity in inflammatory diseases.
  • Case study on COVID-19 highlights NTCdb's ability to reveal cell, gene, and pathway functions.
  • Identified commonalities among specific immunocytes across different inflammatory conditions.

Conclusions:

  • NTCdb addresses the need for a comprehensive immunocyte database in inflammatory diseases.
  • The database facilitates deeper understanding of disease pathogenesis and immune responses.
  • NTCdb serves as a valuable resource for clinical researchers investigating inflammatory-associated conditions.