Related Experiment Video

Updated: May 6, 2026

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography
10:33

Assessment of Right Ventricular Structure and Function in Mouse Model of Pulmonary Artery Constriction by Transthoracic Echocardiography

Published on: February 3, 2014

27.7K

The Prognostic Value of Left Ventricular Entropy From T1 Mapping in Patients With Hypertrophic Cardiomyopathy

Jie Wang1,2, Jinquan Zhang3, Lutong Pu1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

JACC. Asia
|May 20, 2024
PubMed

Insights

Left ventricular (LV) entropy from T1 mapping predicts sudden cardiac death (SCD) and cardiovascular death (CVD) in hypertrophic cardiomyopathy (HCM) patients. Increased LV entropy indicates higher risk, serving as an independent prognostic marker.

Area of Science:

  • Cardiology
  • Biomedical Imaging
  • Medical Diagnostics

Background:

  • The prognostic implications of left ventricular (LV) entropy in hypertrophic cardiomyopathy (HCM) remain incompletely understood.
  • Assessing myocardial tissue characteristics is crucial for risk stratification in HCM patients.

Purpose of the Study:

  • To evaluate the prognostic value of LV entropy, quantified using T1 mapping, in predicting adverse outcomes in individuals with HCM.
  • To determine if LV entropy can serve as an independent predictor of sudden cardiac death (SCD) and cardiovascular death (CVD) in HCM.

Main Methods:

  • Cardiovascular magnetic resonance (CMR) imaging was performed on 748 participants with HCM.
  • LV entropy was measured using native T1 mapping.
  • Competing risk and Cox regression analyses were employed to assess associations between LV entropy and SCD/CVD.

Main Results:

  • Higher LV entropy (≥4.06) was significantly associated with increased risk of SCD and CVD (P < 0.05).
  • LV mean entropy independently predicted SCD (HR: 1.03) and CVD (HR: 1.06) after adjusting for established risk factors and LGE extent.
  • These findings held true in the overall cohort and in subgroups with low LGE extent.

Conclusions:

  • LV mean entropy, derived from native T1 mapping, reflects myocardial tissue heterogeneity.
  • LV mean entropy is an independent predictor of SCD and CVD in patients with HCM, offering valuable prognostic information.
Abstract

Keywords:
T1 mappingcardiac magnetic resonanceentropyhypertrophic cardiomyopathysudden cardiac death

More Related Videos

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

19.6K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

3.9K

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Mitral Stenosis II: Clinical features and Diagnostic Tests01:23

Mitral Stenosis II: Clinical features and Diagnostic Tests

Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
557
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805