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Impact of Aging on Cardiovascular Diseases: From Chronological Observation to Biological Insights: JACC Family Series
Dong Zhao1, Yibin Wang2, Nathan D Wong3
1Capital Medical University Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
JACC. Asia
|May 20, 2024
Summary
Cardiovascular disease (CVD) poses challenges to healthy aging. This review connects biological aging insights to human population patterns of CVD, offering new perspectives.
Area of Science:
- Gerontology
- Cardiology
- Public Health
Background:
- Cardiovascular disease (CVD) presents significant challenges to healthy aging globally.
- Understanding biological aging processes offers new insights into age-related diseases.
- Existing reviews often focus on animal models, lacking human population data.
Purpose of the Study:
- To highlight key questions in aging-related CVD research.
- To connect biological aging hypotheses with observed human CVD patterns.
- To provide perspectives using multidimensional information and biological insights.
Main Methods:
- Literature review focusing on aging and CVD.
- Analysis of cellular and molecular aging mechanisms.
- Integration of human population data and biological insights.
Main Results:
- Identified gaps in linking animal-based aging research to human CVD.
- Highlighted the need for studies connecting biological aging to real-world CVD patterns.
- Emphasized the importance of multidimensional data in aging-CVD research.
Conclusions:
- Current research on aging and CVD requires better integration of human population data.
- Future studies should bridge cellular/molecular aging insights with epidemiological CVD patterns.
- A multidimensional approach is crucial for understanding and mitigating aging-related CVD.
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