Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Stem Cell Niche01:26

Stem Cell Niche

5.1K
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
5.1K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

2.2K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.2K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.1K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.1K
Cellular Differentiation00:57

Cellular Differentiation

2.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
2.6K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Correlation Between the Prognostic Nutritional Index and Sudden Sensorineural Hearing Loss With Comorbid Nonalcoholic Fatty Liver Disease: A Prospective Study.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Enhancing the rigor and clinical applicability of optical enhancement combined with magnification endoscopy for gastric lesion detection.

Gastrointestinal endoscopy·2026
Same author

Dahuang Gancao decoction suppresses ferroptosis via SIRT3-mediated NRF2 deacetylation in acute kidney injury.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2025
Same author

Estimation performance is modulated by emotional valence and stimulus onset asynchrony (SOA): evidence from priming paradigm.

BMC psychology·2025
Same author

Predictive immunonutritional biomarkers for the severity and recovery of sudden sensorineural hearing loss: a prospective clinical study.

Frontiers in neurology·2025
Same author

Transnasal-brain delivery of nanomedicines for neurodegenerative diseases.

Frontiers in drug delivery·2025

Related Experiment Video

Updated: Jun 26, 2025

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.0K

lncRNAs regulate cell stemness in physiology and pathology during differentiation and development.

Jie Lu1, Li Xu1, Ying Wang1

  • 1Department of Otolaryngology Head and Neck Surgery, Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou, Jiangsu, China.

American Journal of Stem Cells
|May 20, 2024
PubMed
Summary

Long non-coding RNAs (lncRNAs) are crucial for cell development and stemness regulation. Understanding lncRNA functions is key to addressing developmental disorders caused by their mutations.

Keywords:
differentiationlncRNApluripotencyregenerationstemness

More Related Videos

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.1K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

272

Related Experiment Videos

Last Updated: Jun 26, 2025

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes
10:48

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

10.0K
Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
13:03

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues

Published on: June 3, 2016

8.1K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

272

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Background:

  • Long non-coding RNAs (lncRNAs) are abundant, yet their functions are not fully understood.
  • lncRNAs play roles in cell proliferation, differentiation, and cancer.
  • They are involved in regulating cell stemness and developmental processes.

Purpose of the Study:

  • To review current knowledge on lncRNAs in stemness regulation.
  • To discuss the biological functions and mechanisms of lncRNAs in stemness.
  • To highlight the role of lncRNAs in developmental disorders.

Main Methods:

  • Comprehensive literature review of lncRNA research.
  • Analysis of studies on lncRNA functions in stemness.
  • Examination of genetic factors and mutations in lncRNAs.

Main Results:

  • lncRNAs are significant regulators of cell stemness.
  • Specific lncRNAs govern differentiation, regeneration, and stem cell maintenance.
  • Disruptions in lncRNAs are linked to developmental disorders.

Conclusions:

  • lncRNAs are vital for maintaining cell stemness and normal development.
  • Further research into lncRNA mechanisms is crucial for understanding and treating developmental disorders.