Jove
Visualize
Contact Us

Related Concept Videos

JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Combining Kras Gene Status With Preoperative D‑dimer Levels As A Predictive Marker Of Venous Thromboembolism Risk In Patients With Resectable Colorectal Cancer: A Prospective Cohort Study.
  1. Home
  3. Combining Kras Gene Status With Preoperative D‑dimer Levels As A Predictive Marker Of Venous Thromboembolism Risk In Patients With Resectable Colorectal Cancer: A Prospective Cohort Study.

Related Experiment Video

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K

Combining KRAS gene status with preoperative D‑dimer levels as a predictive marker of venous thromboembolism risk in

Duogang Xu1,2, Yulei He3, Changkang Liao1,2

  • 1Department of General Surgery, Yan'an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan 650051, P.R. China.

Biomedical Reports
|May 20, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
D-dimerKRAScolorectal cancerhypercoagulable statevenous thromboembolism

More Related Videos

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

13.7K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

252

Related Experiment Videos

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

5.5K
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

13.7K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

252

KRAS mutations in colorectal cancer (CRC) are linked to a hypercoagulable state, indicated by higher D-dimer levels. This finding may help predict venous thromboembolism (VTE) risk in CRC patients.

Area of Science:

  • Oncology
  • Hematology
  • Genetics

Background:

  • Colorectal cancer (CRC) frequently presents with thrombotic complications.
  • Understanding the link between tumor genetics and hypercoagulability is crucial for improved patient outcomes.

Purpose of the Study:

  • To investigate the association between KRAS mutations and hypercoagulability in operable CRC.
  • To evaluate the prognostic value of preoperative D-dimer levels for venous thromboembolism (VTE) risk.

Main Methods:

  • Prospective analysis of 333 operable CRC patients.
  • Assessed KRAS mutations in 56 cases; D-dimer levels, vascular invasion, and distant metastases were recorded.
  • Diagnosed VTE using doppler or CT angiography.

Main Results:

  • KRAS mutations correlated with significantly elevated preoperative D-dimer levels (1,076 µg/l vs. 485 µg/l).
  • Elevated D-dimer was associated with vascular invasion, distant metastases, and increased postoperative VTE risk.
  • KRAS mutations, distant metastases, and vascular invasion were independent predictors of elevated D-dimer.

Conclusions:

  • KRAS mutation status, distant metastasis, and vascular invasion are independent risk factors for hypercoagulability in CRC.
  • These factors may serve as prognostic indicators for VTE risk, aiding therapeutic strategy development.