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Updated: Jun 26, 2025
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Author Spotlight: In Vitro Investigations of Circadian Rhythms in Multicellular Systems
Published on: February 16, 2024
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Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host
Maria F Gonzalez-Aponte1, Anna R Damato1, Tatiana Simon1
1Department of Biology, Division of Biology and Biomedical Sciences, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Biorxiv : the Preprint Server for Biology
|May 20, 2024
Summary
Glioblastoma growth is influenced by the body's internal clock. Timing medication like Dexamethasone can impact tumor progression, suggesting circadian rhythms are key in brain tumor treatment.
Area of Science:
- Neuro-oncology
- Chronobiology
- Molecular biology
Background:
- Glioblastoma (GBM) is an aggressive brain tumor with poor patient survival.
- Recent studies suggest time-of-day administration of chemotherapy may impact GBM outcomes.
- Circadian rhythms, the body’s natural 24-hour cycles, are increasingly recognized for their role in physiological processes.
Conclusions:
- Glioblastoma (GBM) entrains to the host’s circadian rhythm via brain signaling.
- Host circadian cues, particularly glucocorticoids, modulate GBM growth.
- Targeting circadian signaling pathways presents a potential therapeutic strategy for glioblastoma.
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