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Spike-wave discharges during low-current thalamic deep brain stimulation in mice
Biorxiv : the Preprint Server for Biology
|May 20, 2024
Summary
Deep brain stimulation of the central thalamus (CT-DBS) can induce spike-wave discharges (SWDs) in mice. Close monitoring of EEG is crucial during CT-DBS to mitigate risks.
Area of Science:
- Neuroscience
- Neuromodulation
Background:
- Deep brain stimulation of the central thalamus (CT-DBS) shows promise for consciousness modulation.
- CT-DBS carries a risk of inducing spike-wave discharges (SWDs).
Conclusions:
- A small but significant probability of inducing SWDs exists with CT-DBS.
- Continuous EEG monitoring is essential in research and clinical CT-DBS applications.
- Low current stimulation does not eliminate the risk of SWDs.

