Serum Klotho and FGF23 Levels in Patients with Schizophrenia
Aslı Kazgan Kılıçaslan1, Sevler Yıldız2, Burcu Sırlıer Emir3
1Department of Psychiatry, Bozok University, Yozgat, Turkey.
Psychiatry and Clinical Psychopharmacology
|May 20, 2024
Summary
Serum levels of Klotho and fibroblast growth factor 23 are elevated in schizophrenia patients compared to healthy individuals. This suggests the Klotho/fibroblast growth factor 23 pathway may be involved in schizophrenia pathogenesis.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Schizophrenia pathogenesis involves inflammatory processes.
- Klotho and fibroblast growth factor 23 (FGF23) are proteins with roles in cellular regulation and inflammation.
- Previous research has not extensively explored the relationship between Klotho, FGF23, and schizophrenia.
Purpose of the Study:
- To compare serum Klotho and FGF23 levels in schizophrenia patients versus healthy controls.
- To investigate the correlation between serum Klotho and FGF23 levels in individuals with schizophrenia.
- To explore the potential role of the Klotho/FGF23 pathway in schizophrenia.
Main Methods:
- A case-control study involving 40 male schizophrenia patients and 40 healthy male controls.
- Serum Klotho and FGF23 levels were measured using enzyme-linked immunosorbent assay (ELISA).
- Sociodemographic data and clinical scales (PANSS, CGI) were collected.
Main Results:
- Schizophrenia patients exhibited significantly higher serum levels of both Klotho and FGF23 compared to healthy controls (P=.048 and P=.010, respectively).
- A strong positive correlation was found between serum Klotho and FGF23 levels in all subjects (r=0.816; P < .001).
Conclusions:
- This study is the first to report elevated serum Klotho and FGF23 levels in schizophrenia patients.
- The Klotho/FGF23 pathway may be implicated in the pathophysiology of schizophrenia.
- Investigating Klotho and FGF23 in inflammation could offer new avenues for understanding schizophrenia etiology and treatment.
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