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Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
Infant Feeding for Persons Living With and at Risk for HIV in the United States: Clinical Report
Lisa Abuogi1, Lawrence Noble2, Christiana Smith1
1Section of Infectious Diseases, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Insights
For parents with HIV on antiretroviral treatment (ART) with viral suppression, breastfeeding poses a less than 1% HIV transmission risk. Pediatricians should offer nonjudgmental support for breastfeeding while recommending against it if ART or viral suppression is absent.
Area of Science:
- Pediatric Health
- Infectious Disease
- Public Health
Background:
- Infants born to people with HIV require specific feeding guidance.
- Healthcare providers must understand HIV transmission risks via breastfeeding.
- Current US recommendations balance risk reduction with family-centered care.
Purpose of the Study:
- To inform pediatric health professionals about infant feeding recommendations for infants with perinatal HIV exposure.
- To outline harm reduction strategies for parents with HIV who wish to breastfeed.
- To emphasize the importance of antiretroviral treatment (ART) and viral suppression.
Main Methods:
- Review of current guidelines from the American Academy of Pediatrics.
- Analysis of HIV transmission risks associated with breastfeeding.
- Discussion of harm reduction approaches in pediatric HIV care.
Main Results:
- Breastfeeding from a parent with HIV on ART and viral suppression has <1% transmission risk.
- The only 0% risk option is avoidance of breastfeeding for people with HIV in the US.
- Counseling should recommend against breastfeeding if ART is not used or viral suppression is not achieved.
Conclusions:
- Pediatricians should adopt a nonjudgmental, harm reduction approach for HIV-positive parents desiring to breastfeed on ART.
- HIV testing and pre-exposure prophylaxis (PrEP) are crucial for pregnant and breastfeeding individuals at high risk.
- Clear guidance is needed to support informed infant feeding decisions for families affected by HIV.
Abstract:
Pediatricians and pediatric health care professionals caring for infants born to people living with and at risk for HIV infection are likely to be involved in providing guidance on recommended infant feeding practices. Care team members need to be aware of the HIV transmission risk from breastfeeding and the recommendations for feeding infants with perinatal HIV exposure in the United States. The risk of HIV transmission via breastfeeding from a parent with HIV who is receiving antiretroviral treatment (ART) and is virally suppressed is estimated to be less than 1%. The American Academy of Pediatrics recommends that for people with HIV in the United States, avoidance of breastfeeding is the only infant feeding option with 0% risk of HIV transmission. However, people with HIV may express a desire to breastfeed, and pediatricians should be prepared to offer a family-centered, nonjudgmental, harm reduction approach to support people with HIV on ART with sustained viral suppression below 50 copies per mL who desire to breastfeed. Pediatric health care professionals who counsel people with HIV who are not on ART or who are on ART but without viral suppression should recommend against breastfeeding. Pediatric health care professionals should recommend HIV testing for all pregnant persons and HIV preexposure prophylaxis to pregnant or breastfeeding persons who test negative for HIV but are at high risk of HIV acquisition.
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