Related Experiment Video
Updated: Jun 26, 2025
12:16
Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
Published on: March 13, 2013
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Characteristics and significance of programmed cell death-related gene expression signature in skin cutaneous
Xiaoxia Wu1, Suhong Chen2, Qingfa Ji3
1Department of Dermatology, The 95th Hospital of Putian, Putian, Fujian, China.
Summary
Programmed cell death (PCD) pathways are vital in skin cutaneous melanoma (SKCM). A new cell death index (CDI) effectively predicts patient survival and response to immunotherapy, aiding personalized SKCM treatment.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Programmed cell death (PCD) pathways are critical in skin cutaneous melanoma (SKCM) development.
- Understanding PCD's prognostic role is essential for personalized SKCM treatment strategies.
Purpose of the Study:
- To investigate the prognostic significance of PCD-related genes in SKCM.
- To develop and validate a prognostic cell death index (CDI) for SKCM patients.
Main Methods:
- Analyzed 1466 PCD-related genes from The Cancer Genome Atlas (TCGA)-SKCM cohort.
- Established and validated a prognostic cell death index (CDI) using survival analysis and predictive modeling.
- Performed functional enrichment, PPI, clustering, TME, and drug sensitivity analyses.
Main Results:
- CDI stratified SKCM patients into high and low-risk groups with distinct survival outcomes.
- CDI demonstrated strong predictive value for 1, 3, and 5-year survival (C-index ~0.8, AUC > 0.75).
- CDI correlated with immune response, apoptosis, TME infiltration, and immunotherapy response.
Conclusions:
- PCD-related genes hold significant prognostic value in SKCM.
- CDI is a promising biomarker for predicting SKCM patient outcomes and guiding personalized therapy.
- Further validation and clinical integration of CDI are recommended for improved SKCM management.
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