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Related Experiment Video

Updated: Jun 26, 2025

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
09:12

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

9.6K

Animal models for partial heart transplantation.

Julia Yerger1, Morgan A Hill1, David C Fitzgerald1

  • 1Medical University of South Carolina, Charleston, South Carolina, USA.

Pediatric Transplantation
|May 20, 2024
PubMed
Summary

Partial heart transplantation uses only the heart portion with the valve, sparing native ventricles. Rodent, piglet, and non-human primate models are reviewed for studying this procedure.

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Area of Science:

  • Cardiovascular Surgery
  • Transplantation Biology
  • Animal Models in Research

Background:

  • Partial heart transplantation involves implanting only the valve-bearing portion of a donor heart, preserving the recipient's native ventricles.
  • This approach has significant implications for ischemia time, graft preservation, primary graft dysfunction, immune rejection, and immunosuppression strategies.

Purpose of the Study:

  • To review the utility of animal models for exploring partial heart transplant biology.
  • Experience with partial heart transplantation in rodents, piglets, and non-human primates is examined.

Main Methods:

  • The review is based on extensive experience with partial heart transplantation in over 100 rodents, 50 piglets, and one baboon.
  • Different animal models were utilized, including rodent heterotopic, piglet orthotopic, and non-human primate partial heart xenotransplantation.
Keywords:
animal modelheart valvepartial heart transplantationpediatric cardiac surgery

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A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
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Murine Cervical Heart Transplantation Model Using a Modified Cuff Technique
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Related Experiment Videos

Last Updated: Jun 26, 2025

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
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A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation

Published on: April 27, 2019

9.6K
A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice
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A Novel Microsurgical Model for Heterotopic, En Bloc Chest Wall, Thymus, and Heart Transplantation in Mice

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Murine Cervical Heart Transplantation Model Using a Modified Cuff Technique
10:32

Murine Cervical Heart Transplantation Model Using a Modified Cuff Technique

Published on: October 12, 2014

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Main Results:

  • Rodent models are cost-effective and offer numerous research tools, suitable for heterotopic partial heart transplants due to surgical limitations.
  • Piglet models, comparable in size to children, facilitate orthotopic partial heart transplantation with clinical equipment and allow study of graft growth.
  • Non-human primates, being immunologically similar to humans, are ideal for investigating partial heart transplant immunobiology and xenotransplantation.

Conclusions:

  • Each animal model (rodent, piglet, non-human primate) offers unique advantages for studying specific aspects of partial heart transplantation.
  • Research using these models is crucial for advancing knowledge and improving outcomes for children requiring partial heart transplants, adhering to ethical research principles.