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Updated: Jun 25, 2025

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Application of Human Acellular Dermal Matrix with Skin Graft for Lacunar Soft-Tissue Defect of Lateral Heel after
Xiaoliang Song1, Shuo Zhao, Fengyu Wang
1Xiaoliang Song, MD, is Orthopedic Surgeon, Orthopedic Trauma Department, The Second People's Hospital of Changzhi City, Shanxi Province, China. Shuo Zhao, MD, is Orthopedic Surgeon, Orthopedic Department, Hebei Children's Hospital, Heibei Province, China. Fengyu Wang, MD, is Orthopedic Surgeon, Department of Hand Surgery, The Third Hospital of Hebei Medical University, Hebei Province, China. Yuan Liu, MB, is Orthopedic Surgeon, Department of Trauma and Orthopedics, Handan First Hospital, Handan, China. Also in the Department of Hand Surgery, The Third Hospital of Hebei Medical University, Li Wang, MD, is Associate Professor; Yali Xu, MD, is Professor; Li Lv, MB, is Orthopedic Surgeon; Wenxu Duan, MD, is Orthopedic Surgeon; Hongjuan Zhang, MB, is Chair in Nursing; Runze Bai, MB, is Orthopedic Surgeon; Hejun Sun, MB, is Orthopedic Surgeon; and Xinzhong Shao, MB, is Full Professor.
Objective:
To investigate the clinical effect of human acellular dermal matrix (HADM) combined with split-thickness skin graft in repairing lacunar soft tissue defects of the lateral heel after calcaneal fracture.
Methods:
From June 2018 to October 2020, providers repaired 11 cases of lacunar soft tissue defects at the lateral part of the heel using HADM combined with split-thickness skin graft. After thorough debridement, the HADM was trimmed and filled into the lacunar defect area. Once the wound was covered, a split-thickness skin graft and negative-pressure wound therapy were applied. Providers evaluated the appearance, scar, ductility of the skin graft site, appearance of the donor site, healing time, and any reoperation at follow-up.
Results:
Of the 11 cases, 8 patients achieved successful wound healing by primary intention. Three patients showed partial necrosis in the edge of the skin graft, but the wound healed after standard wound care. Evaluation at 6 and 12 months after surgery showed that all patients had wound healing and mild local scarring; there was no obvious pigmentation or scar formation in the donor skin area. The average healing time was 37.5 days (range, 24-43 days).
Conclusions:
The HADM combined with split-thickness skin graft is a simple and effective reconstruction method for lacunar soft tissue defect of the lateral heel after calcaneal fracture. In this small sample, the combination demonstrated few infections, minor scar formation, few donor site complications, and relatively short hospital stays.
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