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Microglia lactylation in relation to central nervous system diseases
1School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang Province, China.
Neural Regeneration Research
|May 20, 2024
Summary
Microglia lactylation, a process involving lactate, is crucial for central nervous system homeostasis and neurodegenerative disease development. Understanding this mechanism offers new therapeutic targets for brain diseases.
Area of Science:
- Neuroscience
- Immunology
- Metabolism
Background:
- Neurodegenerative diseases disrupt central nervous system (CNS) homeostasis.
- Microglia, the resident immune cells of the CNS, are key players in maintaining CNS health and responding to injury.
- Lactate, once viewed as waste, is now recognized for its vital physiological roles, including lactylation.
Purpose of the Study:
- To review the role of microglia lactylation in CNS homeostasis and neurodegenerative diseases.
- To explore the metabolic and homeostatic regulatory processes of microglia lactylation.
- To discuss therapeutic strategies targeting lactate and lactylation in CNS disorders.
Main Methods:
- Literature review focusing on microglia, lactate metabolism, and lactylation.
- Analysis of research on histone and non-histone lactylation.
- Examination of therapeutic approaches targeting lactate pathways.
Main Results:
- Lactylation is a significant pathway for lactate function, impacting glycolysis, macrophage polarization, and angiogenesis.
- Microglia lactylation is implicated in the pathogenesis of various CNS diseases.
- Histone versus non-histone lactylation presents distinct regulatory mechanisms.
Conclusions:
- Microglia lactylation plays a critical role in CNS homeostasis and disease.
- Further understanding of microglia lactylation's metabolic regulation can lead to novel treatments for CNS diseases.
- Targeting lactate metabolism offers promising therapeutic avenues for neurodegenerative conditions.
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