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Non-coding RNAs in acute ischemic stroke: from brain to periphery.

Shuo Li¹, Zhaohan Xu¹, Shiyao Zhang²

¹Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China.

Neural Regeneration Research

|May 20, 2024

Summary

Non-coding RNAs (ncRNAs) show promise as biomarkers and therapeutic targets for acute ischemic stroke. Research highlights their roles in brain damage and immune responses, offering new clinical applications.

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Area of Science:

Biochemistry
Genetics
Neurology

Background:

Acute ischemic stroke presents significant morbidity and mortality.
Effective biomarkers and therapeutic targets for stroke remain elusive.
Advances in gene sequencing reveal non-coding RNAs (ncRNAs) altered in stroke.

Purpose of the Study:

To review the roles of ncRNAs in acute ischemic stroke pathology.
To explore the potential of ncRNAs as biomarkers for stroke prediction, diagnosis, and prognosis.
To highlight ncRNAs as potential therapeutic targets for stroke.

Main Methods:

Literature review of studies on ncRNAs in acute ischemic stroke.
Analysis of research on ncRNAs in clinical samples and experimental models.
Consolidation of findings on microRNAs, long ncRNAs, and circular RNAs.

Main Results:

Aberrantly expressed ncRNAs are implicated in stroke-induced brain damage.
ncRNAs in peripheral blood show potential as diagnostic and prognostic biomarkers.
ncRNAs in immune cells are involved in post-stroke immune responses.

Conclusions:

ncRNAs play critical roles in the pathological processes of acute ischemic stroke.
ncRNAs offer significant potential as biomarkers for acute ischemic stroke.
ncRNAs represent promising therapeutic targets for acute ischemic stroke management.