Related Experiment Video
Updated: May 11, 2026
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Pediatric renal transplantation: a single center experience
Shakhawan Hama Amin Said1, Saiwan Hayas Agha2, Goran Fryad Abdulla3
1College of Medicine, University of Sulaimani, Sulaymaniyah, Kurdistan. shakhwan.said@gmail.com.
Insights
Pediatric kidney transplantation is effective for end-stage renal disease (ESRD). Reflux nephropathy was the primary cause, and Thymoglobulin was the main immunosuppressant, showing good outcomes in Sulaymaniyah.
Area of Science:
- Pediatric Nephrology
- Transplantation Surgery
- Immunosuppression Therapy
Background:
- Global rise in end-stage renal disease (ESRD) poses significant health challenges, particularly for pediatric populations.
- Children with ESRD face elevated mortality risks despite available renal replacement therapies.
- Kidney transplantation offers superior survival rates compared to other treatments but presents challenges in pediatric cases due to recipient size and donor-recipient matching.
Purpose of the Study:
- To evaluate the outcomes of living donor kidney transplantation in children with ESRD.
- To identify the common causes of renal failure and complications in pediatric kidney transplant recipients.
- To assess the immunosuppressive strategies employed in pediatric kidney transplantation.
Main Methods:
- Retrospective case series study involving pediatric patients with ESRD undergoing kidney transplantation.
- Data collected from two centers in Sulaymaniyah between 2015 and 2021.
- Analysis of patient demographics, etiology of renal failure, surgical procedures, immunosuppression, and complications.
Main Results:
- The study included 39 male and 13 female pediatric patients; donors were predominantly males aged 25-40.
- The majority of recipients were adolescents aged 15-18 years.
- Reflux nephropathy was the most common cause of renal failure; Thymoglobulin was the primary induction immunosuppressant.
- Artery anastomosis was typically performed to the external iliac artery.
- Complications occurred in 9 patients, with 3 experiencing acute rejection.
Conclusions:
- Renal transplantation is the preferred treatment for pediatric end-stage renal disease in Sulaymaniyah.
- Reflux nephropathy is the leading cause of pediatric renal failure in this region, differing from North American studies.
- Living donor kidney transplantation demonstrates feasibility and efficacy in the pediatric population studied.
Introduction:
The rising prevalence of global end-stage renal disease (ESRD) is a significant health concern, especially among children. Although renal replacement therapy is available, children with ESRD are at an increased risk of mortality. Kidney transplantation is the preferred modality of treatment and surpasses renal replacement therapy in terms of survival. However, pediatric renal transplantation could prove difficult due to factors like smaller recipients and donor-recipient mismatches leading to higher complications.
Materials And Methods:
A retrospective single-group case series study was conducted on children with ESRD who were planned to undergo kidney transplantation from living donors between 2015 and 2021. The data was collected from two centers in the city of Sulaymaniyah.
Results:
The study comprised a predominantly male patient population, with a total of 39 individuals (n = 39) and 13 female patients. The donors were mostly males between 25-40 years old. The majority of participants were 15-18 years old. In majority of the patients Thymoglobulin was the immunosuppressive agent used in induction. The most common etiology for renal failure was reflux nephropathy and artery anastomosis was performed to the external iliac artery in the majority of patients. Only 9 patients had complications following the transplantation and 3 patients had an episode of acute rejection.
Conclusions:
Renal transplantation is the preferred treatment of renal failure in pediatric patients in the city of Sulaymaniyah. The most common etiology for pediatric renal failure was reflux nephropathy which was different from the findings of North American Pediatric Renal Trials and Collaborative Studies.
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