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Risk Factors and Mortality Among Women With Interval Breast Cancer vs Screen-Detected Breast Cancer
Huiyeon Song1, Thi Xuan Mai Tran1, Soyeoun Kim2
1Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
JAMA Network Open
|May 20, 2024
Summary
Risk factors for interval breast cancer (IBC) in Korean women include lower breast density and lack of family history. While overall mortality is comparable to screen-detected breast cancer (SBC), early IBC diagnosis is linked to higher mortality.
Area of Science:
- Oncology
- Radiology
- Public Health
Background:
- Interval breast cancer (IBC) risk factors and survival outcomes compared to screen-detected breast cancer (SBC) are understudied in Korean women.
- Understanding these differences is crucial for optimizing breast cancer screening strategies.
Purpose of the Study:
- To evaluate risk factors associated with IBC and survival outcomes in Korean women.
- To compare IBC with SBC in terms of risk factors and mortality.
Main Methods:
- Retrospective cohort study using the Korean National Health Insurance Service Database (2009-2012 screening participants).
- Inclusion of 8702 women with IBC and 9492 women with SBC.
- Mortality outcomes tracked until December 2020.
Main Results:
- Increased mammographic density was associated with a decreased probability of IBC.
- Lower body mass index, postmenopausal status, hormone replacement therapy (HRT) use, and no family history of breast cancer were linked to higher IBC likelihood.
- IBC diagnosed 6-12 months post-screening had higher total and cancer-related mortality than SBC.
Conclusions:
- Breast density, obesity, and HRT use are associated with IBC risk.
- Supplemental breast ultrasound may reduce IBC incidence in women with dense breasts.
- Overall mortality for IBC is comparable to SBC, but early detection (6-12 months) carries higher mortality risks.
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