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Updated: Jun 25, 2025

Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle
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Evaluation of Injury-induced Senescence and In Vivo Reprogramming in the Skeletal Muscle

Published on: October 26, 2017

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A Youthful Touch: Reversal of Aging Hallmarks by Cell Reprogramming

Eleni Miliotou1,2, Irene de Lázaro1,2,3

  • 1Department of Biomedical Engineering, NYU Tandon School of Engineering, New York University, New York, New York, USA.

Cells, Tissues, Organs
|May 20, 2024
PubMed
Abstract

Insights

Cellular reprogramming shows promise for reversing aging hallmarks, potentially extending health span. Further research is crucial to ensure safety and efficacy for clinical anti-aging applications.

Area of Science:

  • Biogerontology
  • Cellular and Molecular Biology
  • Regenerative Medicine

Background:

  • Aging population growth necessitates interventions for age-related diseases.
  • Cellular reprogramming using Oct3/4, Klf4, Sox2, and cMyc (OKSM) transcription factors demonstrates rejuvenating effects.
  • Rejuvenation effects can occur without dedifferentiation or loss of cell identity.

Purpose of the Study:

  • Review evidence on cellular reprogramming's impact on aging hallmarks.
  • Investigate the mechanisms underlying reprogramming-induced rejuvenation.
  • Critically assess challenges for clinical translation of anti-aging interventions.

Main Methods:

  • Literature review of cellular reprogramming studies.
  • Analysis of mechanisms mediating rejuvenation.
  • Assessment of clinical translation challenges.

Main Results:

  • Cellular reprogramming can partially reverse key aging hallmarks.
  • Mechanisms of action are being elucidated.
  • Significant challenges exist in translating reprogramming to clinical practice.

Conclusions:

  • Cellular reprogramming holds potential for partial reversal of aging hallmarks.
  • Further research is needed to confirm biological significance, duration, and safety.
  • Stimulating new research directions for effective health span extension.
Keywords:
AgingAging hallmarksCellular reprogrammingRejuvenation

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