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Related Concept Videos

Overview of Fungi01:29

Overview of Fungi

Fungi are a diverse group of eukaryotes more closely related to animals than other eukaryotes. Fungal cell walls comprise chitin, a polysaccharide that provides structural strength, and glucans, which contribute to flexibility and integrity. Other polysaccharides, such as mannans and galactosans, may supplement or replace chitin in some fungi. These adaptations, along with their preference for acidic environments and tolerance for high osmotic pressure, enable fungi to thrive in various...

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Flow modeling and structural characterization in fungal pellets.

J Sánchez-Vargas1, F J Valdés-Parada2, L Peraza-Reyes3

  • 1Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, 04510, CDMX, Mexico; Posgrado en Ciencias Bioquímicas, Universidad Nacional Autónoma de México, 04510, CDMX, Mexico.

Journal of Theoretical Biology
|May 20, 2024
PubMed
Summary

This study models transport in fungal pellets, crucial for biotechnology. The new upscaled model accurately predicts fluid flow, improving process understanding and applications.

Keywords:
Fluid mechanicsLaccaria trichodermophoraMathematical modelUpscaling

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Area of Science:

  • Multiphase flow modeling
  • Biotechnology
  • Fungal pellet analysis

Background:

  • Fungal pellets are complex hierarchical systems with diverse applications.
  • Modeling transport phenomena in fungal pellets is essential for optimizing biotechnological processes.

Purpose of the Study:

  • To implement and analyze an upscaled model for total mass and momentum transport in fungal pellets.
  • To develop a model that accounts for both intracellular and extracellular phases within the biomass.

Main Methods:

  • Utilized volume averaging and adjoint homogenization methods.
  • Developed effective-medium coefficients by solving adjoint closure problems on representative 3D microstructural domains.
  • Constructed microstructural domains based on Laccaria trichodermophora biological structures.

Main Results:

  • The upscaled model was validated against direct numerical simulations.
  • No significant impact of dolipore status (open/closed) on fluid flow was observed.
  • The contribution of the intracellular fluid phase to overall transport was quantified, differentiating from classical Darcy's law.

Conclusions:

  • The developed upscaled model provides a foundation for studying transport phenomena in fungal pellets.
  • This model enhances understanding of fluid dynamics within fungal biomass.
  • The findings are critical for advancing knowledge-based biotechnological applications involving fungal pellets.