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Updated: Jun 25, 2025

Metagenomic Analysis of Silage
Published on: January 13, 2017
Metabuli: sensitive and specific metagenomic classification via joint analysis of amino acid and DNA
Jaebeom Kim1, Martin Steinegger2,3,4,5
1Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Abstract:
Metagenomic taxonomic classifiers analyze either DNA or amino acid (AA) sequences. Metabuli ( https://metabuli.steineggerlab.com ), however, jointly analyzes both DNA and AA to leverage AA conservation for sensitive homology detection and DNA mutations for specific differentiation of closely related taxa. In the Critical Assessment of Metagenome Interpretation 2 plant-associated dataset, Metabuli covered 99% and 98% of classifications of state-of-the-art DNA- and AA-based classifiers, respectively.
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