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Relationship of Fatigue, Pain Interference, and Physical Disability in Children Newly Diagnosed With Juvenile

Naomi Choong1, Michelle Batthish2, Roberta A Berard3

  • 1British Columbia Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Arthritis Care & Research
|May 21, 2024
PubMed

Insights

In children with juvenile idiopathic arthritis (JIA), fatigue and pain interference are linked to physical disability. Fatigue partially explains how pain interference impacts physical function in JIA patients.

Area of Science:

  • Pediatric Rheumatology
  • Child Health Outcomes
  • Chronic Illness Management

Background:

  • Juvenile idiopathic arthritis (JIA) significantly impacts children's quality of life.
  • Understanding the interplay of fatigue, pain interference, and physical disability is crucial for effective JIA management.

Purpose of the Study:

  • To quantify the relationships among fatigue, pain interference, and physical disability in children with JIA.
  • To determine if fatigue mediates the link between pain interference and physical disability in JIA.

Main Methods:

  • Utilized data from the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry.
  • Employed Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires and the Childhood Health Assessment Questionnaire (CHAQ).
  • Applied correlation, multiple linear regression, and structural equation modeling (SEM) for analysis.

Main Results:

  • Strong correlations were found between fatigue and pain interference (r=0.72) and fatigue and physical disability (r=0.60).
  • Both fatigue and pain interference independently predicted physical disability in JIA patients.
  • SEM confirmed that fatigue partially mediates the relationship between pain interference and physical disability.

Conclusions:

  • Fatigue and pain interference are independent factors associated with physical disability in newly diagnosed JIA.
  • Fatigue plays a partial mediating role in how pain interference affects physical disability in children with JIA.
Abstract

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