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Comparative studies between humans and golden Syrian hamsters via thromboelastography
Ze Yang1,2, Lili Xie2, Jingjing Ba1,2
1School of Laboratory Animal & Shandong Laboratory Animal Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
Animal Models and Experimental Medicine
|May 21, 2024
Summary
Thromboelastography (TEG) reveals that hamsters have stronger coagulation but similar platelet function compared to humans. This makes hamsters a valuable model for studying thrombosis and lipid metabolism disorders.
Area of Science:
- Hemostasis and Thrombosis Research
- Comparative Hematology
- Biomedical Research Models
Background:
- Thromboelastography (TEG) is essential for monitoring platelet function and thrombosis.
- Lipid metabolism disorders are key risk factors for thrombosis.
- Golden Syrian hamsters offer a relevant model due to lipid metabolism similarities and blood volume, aiding thrombosis research.
Purpose of the Study:
- To compare coagulation and platelet function between golden Syrian hamsters and humans using TEG.
- To assess the suitability of hamsters as a model for studying thrombosis mechanisms related to plasma lipids.
Main Methods:
- Whole blood samples from hamsters and humans were analyzed using TEG.
- Coagulation factor, fibrinogen, platelet, and fibrinolytic system functions were evaluated.
- Automated analyzers (ACLTOP750, XN-2000) were used for coagulation and blood routine testing.
Main Results:
- Hamsters demonstrated significantly stronger coagulation factor and fibrinogen function (p<0.0001) and overall coagulation status (p=0.0023) compared to humans.
- Platelet function showed no significant difference between hamsters and humans (p=0.077).
- Hamsters exhibited faster prothrombin time (PT) and activated partial thromboplastin time (APTT) but lower fibrinogen content.
Conclusions:
- TEG effectively evaluates thrombosis and bleeding parameters in hamster whole blood.
- Hamster platelet function closely mimics human platelet function.
- Hamsters present a robust model for thrombosis research due to their significantly stronger coagulation function compared to humans.
