Multimetal exposure: Challenges in diagnostics, prevention, and treatment
Archna Panghal1, Ashima Thakur2, Monika S Deore3
1Department of Pharmacology and Toxicology, Facility for Risk Assessment and Intervention Studies, National Institute of Pharmaceutical Education and Research, SAS Nagar, India.
Journal of Biochemical and Molecular Toxicology
|May 21, 2024
Summary
Heavy metal exposure causes serious health issues and economic problems. Chelation therapy can help reduce toxic metal levels and associated health difficulties.
Area of Science:
- Environmental Science
- Toxicology
- Public Health
Background:
- Heavy metals are toxic and accumulate in the human body.
- Exposure to heavy metals leads to various health disorders and economic impacts.
- Understanding the molecular mechanisms of heavy metal toxicity is crucial.
Purpose of the Study:
- To review the impact of heavy metal exposure on human health and socioeconomics.
- To elucidate the molecular mechanisms underlying heavy metal-induced disorders.
- To discuss preventive and treatment strategies for heavy metal intoxication.
Main Methods:
- Literature review of studies on heavy metal exposure and health effects.
- Analysis of molecular pathways involved in heavy metal toxicity.
- Evaluation of current preventive and treatment approaches.
Main Results:
- Heavy metals cause significant health problems including neurological, cardiac, and reproductive diseases.
- Molecular mechanisms include oxidative stress, neuroinflammation, and protein misfolding.
- Economic consequences are substantial due to health impacts and environmental contamination.
Conclusions:
- A strong correlation exists between heavy metal exposure and various health issues.
- Chelation treatment is a viable strategy to reduce toxic metal burden.
- Preventive measures and effective treatments are essential to mitigate heavy metal toxicity.
