Related Experiment Video For Immune checkpoint inhibitors
Updated: Jun 25, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
Published on: February 7, 2021
[Advances in Pseudoprogression of Immune Checkpoint Inhibitors in Non-small Cell Lung Cancer]
Yajun Tong1, Yong Long2, Fan Zhang2
1Department of Oncology, Yueyang Central Hospital, Yueyang 414000, China.
Abstract:
The advent of immune checkpoint inhibitors (ICIs) has greatly improved the prognosis of advanced lung cancer patients, but can lead to pseudoprogression (PsP), which complicates clinical evaluation and management. PsP is manifested as temporary enlargement of the tumour or the appearance of new lesions, etc., and improvement in imaging occurs with continued treatment, mostly without worsening of clinical symptoms. Currently, there are still difficulties in the early diagnosis of PsP, and its occurrence mechanism is not yet clear, lacking good predictive factors and related biomarkers. This article reviews the current research status of PsP of ICIs in non-small cell lung cancer in order to provide helpful clinical strategies for oncologists using these drugs. .
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