Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

1.3K
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

1.8K
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
1.8K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.9K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.9K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

753
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
753

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diastolic echocardiographic parameters identify pediatric kidney transplant recipients with structural myocardial alterations.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Author Correction: Injured epithelial cell states impact kidney allograft survival after T-cell-mediated rejection.

Nature communications·2026
Same author

Correction: Correlation of retinal vascular characteristics with laboratory and ocular findings in Fabry disease: exploring ocular diagnostic biomarkers.

Orphanet journal of rare diseases·2026
Same author

Urinary Albumin-to-Creatinine Associates More Closely than Protein-to-Creatinine Ratio with Kidney Outcomes in Pediatric Chronic Kidney Disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same author

A Switch in Iron Delivery Is Critical for Postnatal Kidney Development.

Kidney360·2026
Same author

Differences in Mortality by Donor Sex and Age in a Multinational Cohort of Liver Transplant Recipients.

Transplantation direct·2026

Related Experiment Video

Updated: May 5, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

24.4K

Left Ventricular Hypertrophy After Renal Transplantation: Systematic Review and Meta-analysis.

Zhejia Tian1, Kai Bergmann1, Jessica Kaufeld1

  • 1Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Transplantation Direct
|May 21, 2024
PubMed
Summary

Kidney transplantation may offer cardiovascular benefits by reducing left ventricular hypertrophy (LVH). Improved blood pressure control, not the transplant itself, appears to drive this LVH regression in end-stage renal disease patients.

More Related Videos

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.5K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

712

Related Experiment Videos

Last Updated: May 5, 2026

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

Published on: September 25, 2017

24.4K
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.5K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

712

Area of Science:

  • Nephrology and Cardiology
  • Cardiovascular Health in Renal Disease
  • Renal Replacement Therapy Outcomes

Background:

  • Left ventricular hypertrophy (LVH) is a significant risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients.
  • Renal replacement therapy, including dialysis and kidney transplantation (KT), has varying effects on LVH.
  • Evidence regarding the impact of KT on LVH requires further exploration.

Purpose of the Study:

  • To investigate the relationship between kidney transplantation (KT) and left ventricular hypertrophy (LVH) in ESRD patients.
  • To analyze changes in left ventricular mass index (LVMI) following KT.
  • To identify factors influencing LVMI changes post-transplantation.

Main Methods:

  • Systematic literature search of MEDLINE and Scopus databases (October 2023).
  • Inclusion of cross-sectional and longitudinal studies assessing LVMI changes.
  • Meta-analysis using a random effects model and meta-regression for covariate analysis.

Main Results:

  • 46 studies with 4122 participants were included; longitudinal data showed LVMI improvement post-KT (-0.44 g/m²).
  • Blood pressure, younger age at KT, and controlled anemia were associated with LVH regression.
  • No significant difference in LVMI was detected between dialysis patients and transplant recipients in direct comparisons.

Conclusions:

  • Kidney transplantation may confer cardiovascular benefits through LVH regression.
  • Improved blood pressure control is a key driver of LVH regression post-KT.
  • The benefits observed are likely linked to management of comorbidities rather than transplantation alone.