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Chlamydia pneumoniae in Alzheimer's disease pathology

Lalita Subedi1,2, Bhakta Prasad Gaire3, Yosef Koronyo3

  • 1Department of Pediatrics, Division of Infectious Diseases and Immunology, Guerin Children's at Cedars-Sinai Medical Center, Los Angeles, CA, United States.

Frontiers in Neuroscience
|May 21, 2024
PubMed

Insights

Chlamydia pneumoniae (Cp) is investigated for its potential role in Alzheimer's disease (AD) pathogenesis. This review explores evidence linking Cp to AD brains and discusses potential mechanisms connecting this bacterium to AD pathology.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Pathology

Background:

  • Alzheimer's disease (AD) lacks effective treatments, necessitating research into novel etiologies.
  • Microbial infections are increasingly implicated in AD pathogenesis, with several microbes detected in AD brains.
  • Chlamydia pneumoniae (Cp) is a bacterial pathogen identified in human AD brains, making it a key focus for infectious involvement.

Purpose of the Study:

  • To review current evidence on the role of Chlamydia pneumoniae in human Alzheimer's disease brains.
  • To examine experimental models investigating the link between Cp and AD.
  • To identify potential mechanistic pathways connecting Cp infection to AD pathology and cognitive decline.

Main Methods:

  • Literature review of studies on Chlamydia pneumoniae in Alzheimer's disease.
  • Analysis of findings from postmortem human brain tissues.
  • Examination of data from experimental AD models.

Main Results:

  • Chlamydia pneumoniae has been identified in human AD brain tissues.
  • Experimental models provide insights into potential Cp involvement in AD.
  • Mechanistic pathways linking Cp to AD pathology are being elucidated.

Conclusions:

  • While Chlamydia pneumoniae is a candidate for infectious involvement in Alzheimer's disease, definitive proof is lacking.
  • Further research is required to establish a causal or accelerating role for Cp in AD.
  • Understanding the mechanistic links between Cp and AD could reveal new therapeutic targets.
Keywords:
Alzheimer's diseaseChlamydia pneumoniaeamyloid beta-protein (Aβ) plaqueinfectionmicrobes

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