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Related Experiment Videos

Cefpiramide: comparative in-vitro activity and beta-lactamase stability.

A L Barry, R N Jones, C Thornsberry

    The Journal of Antimicrobial Chemotherapy
    |September 1, 1985
    PubMed
    Summary

    Cefpiramide is a new cephalosporin antibiotic effective against common bacterial pathogens, including Pseudomonas species. It shows broad-spectrum activity but is susceptible to beta-lactamase hydrolysis.

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    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Cefpiramide is a novel cephalosporin antibiotic.
    • It exhibits broad-spectrum antibacterial activity.
    • Its activity profile is compared to cefoperazone.

    Purpose of the Study:

    • To evaluate the antibacterial spectrum and clinical effectiveness of cefpiramide.
    • To compare cefpiramide's activity against Gram-negative bacilli, particularly Pseudomonas species, with cefoperazone.
    • To assess cefpiramide's susceptibility to beta-lactamase hydrolysis.

    Main Methods:

    • Antimicrobial susceptibility testing was performed on 6552 bacterial isolates from five medical centers.
    • Comparative studies were conducted on 761 selected isolates representing 35 species.

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  • Minimum inhibitory concentrations (MICs) were determined for various bacterial pathogens.

    • Main Results:

    • Cefpiramide demonstrated effectiveness against common bacterial pathogens.
    • It showed enhanced activity against Acinetobacter spp. and Pseudomonas spp. compared to cefoperazone.
    • The antibiotic was susceptible to hydrolysis by various beta-lactamases from Gram-negative bacilli.
    • Cefpiramide inhibited methicillin-susceptible staphylococci, non-enterococcal streptococci, Neisseria gonorrhoeae, N. meningitidis, and beta-lactamase-negative Haemophilus influenzae.
    • Marginal activity was observed against Streptococcus faecalis (MIC50, 8.0 mg/L).

    Conclusions:

    • Cefpiramide is a promising Pseudomonas-active cephalosporin with broad-spectrum efficacy.
    • Its susceptibility to beta-lactamases warrants consideration in clinical applications.
    • Further research may explore its therapeutic potential in treating infections caused by susceptible pathogens.