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Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
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Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of...
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Supramolecular cage-mediated cargo transport.

Qing-Hui Ling1, Zhen-Chen Lou1, Lei Zhang2

  • 1State Key Laboratory of Petroleum Molecular and Process Engineering, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Wuhu Hospital Affiliated to East China Normal University (The Second People's Hospital of Wuhu), Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200241, China. txjin@hsc.ecnu.edu.cn.

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Summary

Supramolecular cages mimic nature's transport systems, acting as carriers and channels for cargo. This review covers their development and future potential in both abiotic and biological applications.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Material transport is vital for life, with nature utilizing carriers and channels.
  • Supramolecular cages, inspired by nature, offer unique structures for cargo transport.
  • These cages possess excellent physicochemical properties beneficial for various applications.

Purpose of the Study:

  • To review the advancements in supramolecular cages as carriers and channels for cargo transport.
  • To cover developments in both abiotic and biological systems over the last 15 years.
  • To discuss future challenges and potential applications in substance transport.

Main Methods:

  • Literature review focusing on supramolecular cage development.
  • Analysis of cage structures and their transport mechanisms.
  • Synthesis of information on applications in abiotic and biological contexts.

Main Results:

  • Supramolecular cages have shown significant progress as effective cargo carriers.
  • Their unique structures enable controlled release and targeted delivery.
  • Applications span from drug delivery to molecular machines.

Conclusions:

  • Supramolecular cages represent a promising platform for advanced material transport.
  • Continued research will unlock new possibilities in nanotechnology and medicine.
  • Addressing challenges will enhance their utility in complex systems.