Analysis of antipyretics by semimicro liquid chromatography

Using semimicro columns (150 X 1 mm I.D.) of octadecyl silica and styrene-divinylbenzene porous polymer, antipyretic drugs were analyzed by means of high-performance liquid chromatography. The antipyretics studied were sulpyrin, caffeine, guaiacol glycerol ether, acetaminophen, 3-hydroxy-p-butyrophenetidine, methyl p-hydroxybenzoate, phenacetin, mefenamic acid, aspirin, salicylamide, salicylic acid, o-ethoxybenzamide, theobromine, theophylline and their preparations. The semimicro columns are economical in solvents in chromatographic analysis.