Plasma cholesterol response to a change in dietary fat intake: a collaborative twin study

The rise of plasma cholesterol in response to an increase from 8 to 22.3% in saturated fatty acid of total intake was studied by comparing the concordance of change in pairs of young English and Italian monozygotic (33 pairs) and dizygotic (22 pairs) twins. LDL and total cholesterol rose about 0.6 mmol/l. All methods of analyses showed a marked genetic component influencing total and LDL cholesterol level. However, the genetic component of the increase in LDL and total cholesterol levels was small in Italy and absent in England. These results suggest that the response of plasma cholesterol to this dietary change is largely determined by environmental factors rather than inheritance.