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Updated: Jun 25, 2025
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
Published on: July 5, 2021
Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)
Jatin P Shah1, Helena Levyn1, Cristina Valero1
1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Background:
The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.
Patients And Methods:
A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
Results:
The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
Conclusion:
The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
