Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

363
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
363
Gas Chromatography: Types of Detectors-I01:21

Gas Chromatography: Types of Detectors-I

407
There are different types of detectors used in gas chromatography, each with its own specific properties that make it suitable for detecting certain types of analytes. The most commonly used detectors in GC are thermal conductivity detector (TCD), flame ionization detector (FID), and electron capture detector (ECD).
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
407
Gas Chromatography: Overview of Detectors01:13

Gas Chromatography: Overview of Detectors

506
Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
506
Activation and Inactivation of G Proteins01:22

Activation and Inactivation of G Proteins

7.0K
Heterotrimeric G proteins are guanine nucleotide-binding proteins. As the name suggests, heterotrimeric G proteins are composed of three subunits: alpha, beta, and gamma. They remain GDP-bound or GTP-bound inside the cells and switch between inactive/active states. The Gα subunit possesses the nucleotide-binding pocket that binds guanine nucleotides and switches between GDP or GTP-bound states. In contrast, the Gꞵ and Gγ subunits are always bound together with high...
7.0K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

11.8K
G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.8K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

4.6K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vapor-phase synthesis of high-flux zeolitic imidazolate framework membranes within confined nanochannels for gas separation.

Nanoscale·2026
Same author

Closed-Loop digital therapeutics empowered by deep reinforcement learning and wearable sensing for precision orthopedic rehabilitation: a simulation-based proof-of-concept study.

Frontiers in rehabilitation sciences·2026
Same author

Neuroticism, perceived stress, psychological resilience, and pre-dive state anxiety in professional divers: a cross-sectional study.

BMC psychology·2026
Same author

Analysis of factors influencing hospitalization cost and medical security level of patients with bronchial and pulmonary malignant tumors - a retrospective study in Changzhi, China.

BMC health services research·2026
Same author

Iron-based anodes facilitate concurrent mercury removal and bioenergy generation in constructed wetland-microbial fuel cells.

Bioresource technology·2026
Same author

Use of clips to prevent delayed post-polypectomy bleeding in non-pedunculated colorectal lesions: protocol for a systematic review and meta-analysis.

BMJ open·2026

Related Experiment Video

Updated: Jun 25, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
10:16

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

44.2K

Electronic Effect Driven Specific and Sensitive Recognition toward GHB.

Shi Zhang1,2, Yuan Liu1,3, Jiahao Dong1

  • 1Xinjiang Key Laboratory of Trace Chemical Substances Sensing, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.

Analytical Chemistry
|May 21, 2024
PubMed
Summary
This summary is machine-generated.

A novel electronic-effect strategy enables sensitive detection of gamma-hydroxybutyric acid (GHB), an illicit drug. This method uses a portable chip for covert, real-time identification, enhancing public safety.

More Related Videos

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.2K
Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue
07:09

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Published on: May 9, 2019

8.1K

Related Experiment Videos

Last Updated: Jun 25, 2025

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
10:16

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

44.2K
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
07:51

Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection

Published on: February 1, 2022

3.2K
Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue
07:09

Preparation and Application of a New Bacterial Biosensor for the Presumptive Detection of Gunshot Residue

Published on: May 9, 2019

8.1K

Area of Science:

  • Analytical Chemistry
  • Chemical Sensing
  • Forensic Science

Background:

  • Detecting trace substances with weak chemical activity and simple structures is challenging.
  • Existing methods struggle with analytes lacking distinct spatial features or reactive sites.

Purpose of the Study:

  • To develop a sensitive and specific detection method for gamma-hydroxybutyric acid (GHB).
  • To address the limitations of current techniques for identifying simple, weakly active molecules.

Main Methods:

  • An electronic-effect-driven recognition strategy was employed.
  • A sensing system with two probes (nitro- and hydrogen-substituted) was designed.
  • A portable, eyeshadow box-like sensing chip was fabricated.

Main Results:

  • The sensing system exhibited yellow coloring and blue fluorescence.
  • High sensitivity (0.586 ng/mL) and a fast response time (0.2 s) were achieved.
  • Specific recognition of GHB was demonstrated, even with 22 interferents present, and validated in liquor samples.

Conclusions:

  • The electronic-effect strategy provides a new approach for detecting analytes with weak activity and simple structures.
  • The developed portable sensing chip is reliable for covert GHB detection in real-world scenarios.
  • This work advances chemical sensing for illicit drug identification and public safety applications.