Prognostic significance and value of further classification of lymphovascular invasion in invasive breast cancer: a retrospective observational study

Yuyang Zhang ¹, Huali Wang ², Huahui Zhao ¹

⁰Department of Breast Surgery, The First Affiliated Hospital of Dalian Medical University, No. 193, Union Road, Shahekou District, Dalian, Liaoning, China.

Breast Cancer Research and Treatment +

|

May 21, 2024

View abstract on PubMed

Summary

Lymphovascular invasion in invasive breast cancer is a poor prognostic factor impacting survival. Identifying lymphatic vessel invasion using markers like D2-40 improves diagnosis and predicts recurrence.

Area Of Science

Oncology
Pathology
Cancer Research

Background

Lymphovascular invasion (LVI) is a critical indicator in invasive breast cancer prognosis.
Understanding LVI's role and refining its detection are essential for patient management.

Purpose Of The Study

To evaluate the prognostic significance of LVI in invasive breast cancer.
To assess the utility of specific vascular endothelial markers in classifying LVI.

Main Methods

Analysis of 2124 invasive breast cancer patients' data (2012-2020).
Statistical investigation of LVI correlation with clinicopathological features and survival (OS, DFS).
Immunohistochemical staining (D2-40, CD34) to classify LVI and assess its relation to progression.

Main Results

LVI strongly correlates with T stage, N stage, and nerve invasion.
LVI is an independent poor prognostic factor for overall survival (OS) and disease-free survival (DFS), particularly in Luminal B, triple-negative, and Her-2+ subtypes.
D2-40 positivity in LVI is linked to N stage and localized recurrence.

Conclusions

LVI signifies aggressive features and is an independent poor prognostic factor in invasive breast cancer.
Lymphatic vessel invasion impacts breast cancer recurrence and lymph node metastasis.
Immunohistochemistry for LVI should be integrated into routine diagnostics.

Keywords:

Breast cancer Lymphovascular invasion Prognosis Specific vascular endothelial marker