Association between Psoriasis and MTHFR polymorphisms: a systematic review and meta-analysis

Area of Science:

• Genetics
• Dermatology
• Biochemistry

Background:

• Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in folic acid metabolism.
• Mutations in MTHFR can lead to elevated homocysteine levels, a risk factor for cardiovascular disease.
• Psoriasis patients sometimes exhibit hyperhomocysteinemia, suggesting a potential link.

Purpose of the Study:

• To investigate the association between MTHFR gene polymorphisms (C677T and A1298C) and psoriasis.
• To synthesize existing evidence through a systematic review and meta-analysis.

Main Methods:

• A systematic literature search was performed across major databases (MEDLINE, Embase, Cochrane CENTRAL, Web of Science).
• Included studies were case reports, case-control, cohort, and cross-sectional studies published in English.
• Meta-analysis utilized a random effects model to pool odds ratios (ORs).

Main Results:

• Meta-analysis of 10 studies (1965 psoriasis patients, 2030 controls) revealed significant associations for MTHFR C677T polymorphism across multiple models (allele contrast, additive, dominant, recessive).
• Significant associations were also found for MTHFR A1298C polymorphism in allele contrast, dominant, and overdominant models.
• Pooled ORs indicated a higher likelihood of psoriasis with specific MTHFR genotypes.

Conclusions:

• The study suggests a potential link between MTHFR C677T and A1298C polymorphisms and the diagnosis of psoriasis.
• These genetic variations may contribute to the underlying mechanisms or risk factors associated with psoriasis development.