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Autoimmune Rheumatic Diseases and Outcomes Following Percutaneous Coronary Intervention: A Systematic Review and
Song Peng Ang1, Jia Ee Chia2, Kanchan Misra3
1Department of Internal Medicine, Rutgers Health/Community Medical Center, Toms River, NJ, USA.
Angiology
|May 21, 2024
Summary
Patients with autoimmune rheumatic diseases (AIRDs) face higher risks of death and major adverse cardiovascular events after percutaneous coronary intervention (PCI). These findings highlight suboptimal long-term outcomes in AIRD patients post-PCI.
Area of Science:
- Cardiology
- Rheumatology
- Clinical Outcomes Research
Background:
- Autoimmune rheumatic diseases (AIRDs) are linked to increased cardiovascular mortality.
- Limited and conflicting data exist regarding post-percutaneous coronary intervention (PCI) outcomes in AIRD patients.
Purpose of the Study:
- To systematically review and meta-analyze clinical outcomes after PCI in patients with AIRDs.
- To assess the association between AIRDs and long-term adverse events following PCI.
Main Methods:
- Systematic review and meta-analysis of 9 studies.
- Inclusion of 7,027,270 patients (126,914 with AIRD).
- Analysis of all-cause mortality and major adverse cardiovascular events (MACE).
Main Results:
- AIRD patients were older, predominantly female, with higher rates of hypertension and diabetes.
- AIRD patients had significantly higher odds of all-cause mortality (OR 1.45) and MACE (OR 1.63) post-PCI.
- Rheumatoid arthritis patients showed elevated odds for all-cause mortality and MACE.
Conclusions:
- Autoimmune rheumatic diseases are associated with suboptimal long-term outcomes after PCI.
- AIRD patients experience increased risks of mortality and MACE following PCI.
- Further research is needed to identify risk factors for poor prognosis in AIRD patients undergoing PCI.
