Posterior cingulate epilepsy: Seizure semiology and intracranial electrical stimulation using SEEG
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View abstract on PubMed
Summary
This summary is machine-generated.Posterior cingulate epilepsy (PCE) seizures manifest differently based on origin and spread. Intracranial electrical stimulation (iES) mapping of the posterior cingulate cortex (PCC) can identify seizure onset zones (SOZ).
Area Of Science
- Neuroscience
- Epileptology
- Clinical Neurology
Background
- The posterior cingulate cortex (PCC) plays a crucial role in various cognitive functions.
- Understanding epilepsy originating from the PCC (posterior cingulate epilepsy, PCE) is essential for effective treatment.
- Stereoelectroencephalography (SEEG) is a valuable tool for investigating focal epilepsy.
Purpose Of The Study
- To explore seizure semiology in PCE using SEEG.
- To investigate the effects of intracerebral electrical stimulation (iES) on the PCC.
- To enhance comprehension of PCE by identifying seizure onset zones (SOZ) within PCC subregions.
Main Methods
- Analysis of 59 seizures from 15 patients using SEEG recordings.
- Video documentation of seizure characteristics.
- Assessment of iES outcomes and correlation with semiology and anatomical locations within the PCC.
Main Results
- Behavioral arrest was the most common seizure manifestation across PCC subregions.
- Seizure semiology varied with SOZ location; ventral PCC (vPCC) seizures with temporal spread showed automatism.
- Retrosplenial cortex (RSC) involvement was linked to complex motor behavior and temporal lobe spread; PCC seizures included axial tonic and autonomic events.
- iES in the PCC elicited vestibular, visual, psychological, and autonomic responses, with specific subregion correlations (dPCC, RSC, vPCC).
Conclusions
- PCE seizure manifestations are dependent on the SOZ and propagation patterns.
- iES-induced seizures are rare, highlighting the utility of PCC mapping for pinpointing primary seizure sectors.
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