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Related Experiment Video

Updated: Jun 25, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Soft yet mechanically robust injectable alginate hydrogels with processing versatility based on

Xiaoyu Cao¹, Lei Ma¹, Yunfei Tan¹

¹National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China.

International Journal of Biological Macromolecules

|May 21, 2024

Summary

Researchers developed injectable alginate hydrogels using a novel calcium phosphate-alginate hybrid. This innovation overcomes dispersion challenges, enabling uniform gelation for advanced material applications.

Keywords:

CaP-alginate hybrid Injectable alginate hydrogel Organic/inorganic interface

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Last Updated: Jun 25, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Generation of Alginate Microspheres for Biomedical Applications

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Published on: August 12, 2012

Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations

Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations

Published on: August 7, 2016

Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Alginate hydrogels are widely used but achieving uniform calcium-induced gelation from solid sources is challenging due to interfacial incompatibility.
Existing methods struggle with the homogeneous dispersion of inorganic calcium sources within soft alginate matrices.
This limits the control over hydrogel properties and overall performance.

Purpose of the Study:

To develop a novel method for preparing injectable alginate hydrogels with homogeneous gelation.
To address the challenge of dispersing inorganic calcium sources within alginate solutions.
To create alginate hydrogels with tunable properties and potential for diverse applications.

Main Methods:

Synthesized calcium phosphate (CaP) within an alginate solution to create CaP-alginate hybrids.
Characterized the nano-scale alginate-hydroxyapatite complex using physicochemical methods.
Dispersed the stable CaP-alginate hybrids in alginate solutions to form injectable hydrogels.

Main Results:

The CaP-alginate hybrids were uniformly dispersed in alginate solutions, even under centrifugation.
Homogeneous gelation occurred, forming soft yet tough hydrogels like transparent sheets and knittable threads.
Tunable gelation time, injectability, and mechanical properties were achieved by adjusting preparation parameters.
The hydrogels exhibited uniform porous structure, excellent swelling, wetting, and cytocompatibility.

Conclusions:

The developed CaP-alginate hybrid is an effective calcium source for homogeneous alginate hydrogel formation.
This organic/inorganic hybridization strategy offers a promising approach for creating advanced functional hydrogels.
The tunable properties and excellent characteristics suggest significant potential in various fields, including tissue engineering and drug delivery.