Related Experiment Video
Updated: Jun 25, 2025
07:49
Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
Published on: June 2, 2022
3.2K
Microbiota modulation in disorders of gut-brain interaction
Giovanni Marasco1, Cesare Cremon1, Maria Raffaella Barbaro2
1IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Italy.
Summary
Altered gut microbiota contributes to gut-brain interaction disorders (DGBI). Modulating the gut microbiota through diet, probiotics, and other therapies offers safe and effective treatment options for conditions like IBS and FD.
Area of Science:
- Gastroenterology
- Microbiology
- Neurogastroenterology
Background:
- Disorders of gut-brain interaction (DGBI) are chronic conditions with gastrointestinal symptoms linked to gut microbiota alterations.
- Irritable bowel syndrome (IBS), functional constipation (FC), and functional dyspepsia (FD) are prevalent DGBI.
Purpose of the Study:
- To review the current understanding of gut dysbiosis in DGBI.
- To discuss strategies for modulating the gut microbiota to treat DGBI.
Main Methods:
- Utilized multi-omics methods for comprehensive gut microbiota assessment.
- Reviewed existing literature on DGBI and microbiota modulation therapies.
Main Results:
- Dietary interventions (e.g., low FODMAPs, soluble fiber) are first-line treatments.
- Probiotics, rifaximin, and fecal microbiota transplantation show promise in managing DGBI.
- Therapies like diet, prebiotics, probiotics, and antibiotics can effectively modulate gut microbiota.
Conclusions:
- Gut microbiota plays a crucial role in DGBI pathogenesis.
- Targeting gut microbiota through various therapeutic strategies is effective for managing DGBI.
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