Propofol ('Diprivan') by intravenous infusion with nitrous oxide: dose requirements and haemodynamic effects

The new formulation of propofol appears to be approximately equipotent to the previous formulation when used as an infusion to supplement nitrous oxide anaesthesia in patients premedicated with morphine. Preliminary haemodynamic studies indicate that the emulsion formulation causes more arterial hypotension than the original Cremophor formulation, though larger numbers are required to confirm this finding.