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Diagnostic value of one-stop CT energy spectrum and perfusion for angiogenesis in colon and rectum cancer

  • 0North China University Of Science And Technology Affiliated Hospital, Tangshan, Hebei, 063000, China.
Bmc Medical Imaging +

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May 21, 2024

|

May 21, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Energy spectrum and perfusion CT accurately predict microvessel density (MVD) in colorectal cancer. These imaging techniques assess tumor angiogenesis, aiding in determining malignancy and metastasis potential.

Area Of Science

  • Radiology
  • Oncology
  • Medical Imaging

Background

  • Microvessel density (MVD) is crucial for assessing colorectal cancer (CRC) angiogenesis and malignancy.
  • Non-invasive methods to predict MVD are essential for treatment planning and prognosis.

Purpose Of The Study

  • To evaluate the predictive value of one-stop energy spectrum CT and perfusion CT parameters for MVD in colorectal cancer.
  • To correlate CT-derived parameters with pathological MVD levels.

Main Methods

  • Retrospective analysis of 82 CRC patients' CT data.
  • Measurement of energy spectrum parameters (CT values, λ, Iodine Concentration - IC, Normalized Iodine Concentration - NIC) and perfusion parameters (Blood Volume - BV, Blood Flow - BF).
  • Statistical analysis including ROC curves to determine predictive efficacy for high vs. low MVD groups.

Main Results

  • Energy spectrum parameters (CT values, IC, NIC, λ, Eff-Z) and perfusion parameters (BV, BF) were significantly higher in the high MVD group.
  • Arterial phase IC and NIC, and combined IC+NIC showed high predictive value (AUC > 0.9) for MVD.
  • Perfusion parameters BV and BF, especially combined BV+BF, demonstrated excellent diagnostic efficacy (AUC > 0.99) for MVD prediction.

Conclusions

  • One-stop CT energy spectrum and perfusion imaging can accurately reflect MVD in colorectal cancer.
  • These imaging techniques offer insights into tumor angiogenesis, potentially aiding in assessing malignancy, invasion, and metastasis.

Keywords:

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