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Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

618
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
618
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

429
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
429
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

395
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
395
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

1.0K
Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
1.0K
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

73
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
73
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prevention Of Persistent Pain With Lidocaine Infusions In Breast Cancer Surgery (plan): Study Protocol For A Multicenter Randomized Controlled Trial.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prevention Of Persistent Pain With Lidocaine Infusions In Breast Cancer Surgery (plan): Study Protocol For A Multicenter Randomized Controlled Trial.

Related Experiment Video

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

9.3K

Prevention of persistent pain with lidocaine infusions in breast cancer surgery (PLAN): study protocol for a multicenter randomized controlled trial.

James S Khan1, Ian Gilron2, P J Devereaux3

  • 1Department of Anesthesiology & Pain Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. james.khan@medportal.ca.

Trials
|May 22, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Intraoperative intravenous lidocaine infusion may prevent persistent pain after breast cancer surgery. This study investigates its effectiveness in reducing post-mastectomy pain syndrome (PMPS) and improving survivors' quality of life.

Keywords:
Breast cancer surgeryChronic painChronic postsurgical painLidocaine infusion

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Related Experiment Videos

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
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Area of Science:

  • Oncology
  • Anesthesiology
  • Pain Management

Background:

  • Persistent pain, or post-mastectomy pain syndrome (PMPS), is a significant complication following breast cancer surgery.
  • The increasing number of breast cancer survivors highlights the need for effective pain prevention strategies.
  • Intraoperative intravenous lidocaine infusion is being explored as a potential preventative intervention for PMPS.

Purpose of the Study:

  • To definitively assess the effects of intraoperative intravenous lidocaine infusion on preventing persistent pain after breast cancer surgery.
  • To evaluate lidocaine's impact on reducing the incidence and severity of post-mastectomy pain syndrome (PMPS).

Main Methods:

  • A multicenter, randomized, placebo-controlled trial involving 1,602 patients undergoing breast cancer surgery (lumpectomy or mastectomy).
Perioperative care
Post-mastectomy pain syndrome
  • Participants received either an intravenous lidocaine bolus and infusion or a placebo (normal saline) during surgery.
  • The primary outcome measured was the incidence of persistent pain at 3 months post-surgery.

    • Main Results:

    • The study is designed to provide definitive evidence on lidocaine's efficacy in preventing persistent post-surgical breast cancer pain.
    • Secondary outcomes include pain incidence, opioid consumption, and functional parameters at various time points.
    • Cost-effectiveness analysis will also be conducted.

    Conclusions:

    • Successful outcomes could lead to the integration of lidocaine infusion into standard breast cancer care.
    • This intervention offers a potentially inexpensive and accessible method to reduce pain and suffering in breast cancer survivors.
    • The study aims to decrease chronic pain management costs and potentially reduce opioid use, thereby improving patient quality of life.