Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

2.6K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.6K
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

16.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.7K
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

505
Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
505
Vascular Spasm01:16

Vascular Spasm

1.4K
The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
1.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DAPK2 Regulates PKM2 Phosphorylation at Threonine 45 to Facilitate Disturbed Flow-Induced Atherosclerosis.

Circulation·2026
Same author

The Medical Research Council/British Heart Foundation Centre of Research Excellence in Advanced Cardiac Therapies (REACT).

European heart journal·2025
Same author

Gene therapy in cardiac and vascular diseases: a review of approaches to treat genetic and common cardiovascular diseases with novel gene-based therapeutics.

Cardiovascular research·2025
Same author

Effective Transcriptional Induction of the CARMN/miR-143/145 Complex Locus in Smooth Muscle Cells Using CRISPR Activation.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Pre-clinical studies of Schistosoma mansoni vaccines: A scoping review.

PLoS neglected tropical diseases·2025
Same author

Loss of conserved long non-coding RNA MIR503HG leads to altered NOTCH pathway signalling and left ventricular non-compaction cardiomyopathy.

Cardiovascular research·2025
Same journal

Tangeretin ameliorates sepsis-induced neurocognitive impairment in adult male mice by suppressing Akt-driven glycolytic reprogramming and neuroinflammation.

British journal of pharmacology·2026
Same journal

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having 'bifunctional' bronchodilator and anti-inflammatory activity.

British journal of pharmacology·2026
Same journal

Glucagon-like peptide-1 improves vascular endothelial dysfunction in hypertensive mice via CREB-driven transcriptional regulation of long non-coding RNA 155383.

British journal of pharmacology·2026
Same journal

The chemokine receptor-like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling.

British journal of pharmacology·2026
Same journal

Peripheral targets for neuropathic pain.

British journal of pharmacology·2026
Same journal

Therapeutic potential of liver X receptor agonist GW3965 in preserving myelin integrity following traumatic brain injury.

British journal of pharmacology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2025

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

3.7K

Non-coding RNAs to treat vascular smooth muscle cell dysfunction.

Simon D Brown1, Eftychia Klimi1, Wilfried A M Bakker2

  • 1BHF Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.

British Journal of Pharmacology
|May 22, 2024
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs (ncRNAs) are crucial regulators of vascular smooth muscle cell (vSMC) function. This review explores how ncRNAs like microRNAs, long-non-coding RNAs, and circular RNAs offer therapeutic potential for cardiovascular diseases linked to vSMC dysfunction.

Keywords:
atherosclerosiscardiovascular diseasecircular RNAlong non‐coding RNAmicroRNAnon‐coding RNAtherapeutic oligonucleotidesvascular smooth muscle cell

More Related Videos

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.7K
Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

8.3K

Related Experiment Videos

Last Updated: Jun 25, 2025

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

3.7K
A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics
08:42

A Rat Carotid Balloon Injury Model to Test Anti-vascular Remodeling Therapeutics

Published on: September 19, 2016

8.7K
Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
06:14

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Published on: June 11, 2017

8.3K

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • RNA Therapeutics

Background:

  • Vascular smooth muscle cell (vSMC) dysfunction is a key factor in cardiovascular diseases such as atherosclerosis and restenosis.
  • Non-coding RNAs (ncRNAs) have emerged as critical regulators of vSMC function.
  • Understanding ncRNA roles is vital for developing new cardiovascular therapies.

Purpose of the Study:

  • To provide an in-depth analysis of the mechanisms of vSMC dysfunction.
  • To explore the therapeutic potential of various ncRNAs in preventing or reversing vSMC dysfunction.
  • To review the roles of microRNAs, long-non-coding RNAs, and circular RNAs in vSMC regulation.

Main Methods:

  • Literature review and synthesis of current research on ncRNAs and vSMC biology.
  • Analysis of signalling pathways regulated by ncRNAs in the context of vSMC dysfunction.
  • Discussion of ncRNA-based therapeutic strategies and their associated challenges.

Main Results:

  • ncRNAs, including microRNAs, lncRNAs, and circRNAs, intricately regulate key signalling pathways involved in vSMC dysfunction.
  • These ncRNAs demonstrate significant potential for therapeutic intervention in cardiovascular pathologies.
  • The interplay between different ncRNA types offers complex regulatory mechanisms influencing vSMC fate.

Conclusions:

  • ncRNAs represent a promising frontier for novel therapeutic strategies targeting cardiovascular diseases.
  • Further research into ncRNA mechanisms and delivery systems is essential for clinical translation.
  • Targeting ncRNAs could offer innovative approaches to prevent or reverse vSMC dysfunction and associated pathologies.