Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

147
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
147
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

36
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
36
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

163
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
163
Psychodynamic Therapy01:29

Psychodynamic Therapy

63
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
63
Psychotherapy01:28

Psychotherapy

104
Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
104
Drug Therapy01:28

Drug Therapy

42
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
42

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term aspartame consumption affects global levels of DNA methylation in different types of rat tissues.

Nutrition and health·2026
Same author

Oxa-noribogaine reduces alcohol drinking through aversion learning and by altering glutamatergic activity in the mPFC.

Research square·2026
Same author

From clinical observation to experimental validation: Investigating the neurotoxic impact of dimethylacetamide.

Neurotoxicology·2026
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Basic Science and Pathogenesis.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye.

Frontiers in public health·2025

Related Experiment Video

Updated: Jun 25, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.2K

Psychedelic therapy in depression and substance use disorders.

Nur Damla Korkmaz1,2,3, Ugur Cikrikcili4,5, Merve Akan6

  • 1Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

The European Journal of Neuroscience
|May 22, 2024
PubMed
Summary

Psychedelic therapy, using substances like psilocybin, shows promise for treating depression, anxiety, and substance use disorders. These compounds, acting on serotonin receptors, offer new therapeutic avenues for psychiatric conditions.

Keywords:
anxietydepressionneurobiologypsychedelicssubstance disorders

More Related Videos

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.6K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K

Related Experiment Videos

Last Updated: Jun 25, 2025

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.2K
Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

Published on: January 7, 2019

28.6K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

3.5K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Botanical-derived psychoactive substances have historical and cultural significance.
  • Classical psychedelics, such as psilocybin and lysergic acid diethylamide, modulate perception and cognition via serotonin 5-HT2A receptor activation.
  • Research on psychedelics was restricted post-1967 legislation but has resurged since the 1990s.

Purpose of the Study:

  • To review the historical development of psychedelic therapy.
  • To explore therapeutic applications and treatment potential for psychiatric disorders.
  • To discuss ethical considerations surrounding psychedelic-assisted treatments.

Main Methods:

  • Literature review of historical and contemporary research on psychedelics.
  • Analysis of studies focusing on therapeutic applications, particularly in psychiatry.
  • Examination of the neurobiological mechanisms of psychedelic action.

Main Results:

  • Psychedelic therapy, especially psilocybin-assisted, shows significant potential for treating conditions like cancer-related anxiety, depression, and substance use disorders.
  • These therapies offer new hope for treatment-resistant psychiatric conditions.
  • Psychedelics demonstrate promising efficacy where conventional treatments fall short.

Conclusions:

  • Psychedelic therapy represents a promising frontier in psychiatric treatment.
  • Further research and ethical considerations are crucial for integrating psychedelic therapies.
  • These treatments may revolutionize the management of depression, trauma, and addiction.