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Digital therapeutics using virtual reality-based visual perceptual learning for visual field defects in stroke: A
Eun Namgung1, Sun U Kwon2, Moon-Ku Han3
1Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea.
Brain and Behavior
|May 22, 2024
Summary
Visual perceptual learning (VPL) digital therapeutics show promise for improving vision in poststroke visual field defects (VFDs). While both training types improved visual areas, further research is needed to confirm specific therapeutic advantages.
Area of Science:
- Neuroscience
- Ophthalmology
- Rehabilitation Medicine
Background:
- Poststroke visual field defects (VFDs) are a common and debilitating complication.
- Visual perceptual learning (VPL) offers a potential therapeutic avenue for restoring visual sensitivity in affected individuals.
- Digital therapeutics utilizing VPL present a novel approach to managing VFDs.
Purpose of the Study:
- To investigate the efficacy and safety of VPL-based digital therapeutics (Nunap Vision [NV]) for treating poststroke VFDs.
- To compare the therapeutic effects of NV (defective field training) against a control intervention (NV-C, central field training).
Main Methods:
- A multicenter, double-blind, randomized controlled trial was conducted.
- Stroke patients with VFDs received 12 weeks of virtual reality-based visual perceptual training (NV or NV-C).
- Visual field assessments used Humphrey visual field (HVF) tests at baseline and follow-up.
Main Results:
- Both NV and NV-C groups demonstrated clinically meaningful improvements in visual areas.
- Within-group analysis revealed significant improvement in mean total deviation scores in the defective hemifield after NV training (p=.03).
- No significant between-group differences in therapeutic efficacy were observed.
Conclusions:
- VPL-based digital therapeutics may lead to significant visual improvements in patients with poststroke VFDs.
- Unexpected improvements in the control group suggest potential learning transfer effects.
- Further investigation is warranted to elucidate the specific benefits of NV compared to control interventions.
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